Yeah, you shouldn't have a problem with anything as long as everything is wired properly like mbenonis1 and The_Guest stated.
You run into the problem with long cable runs more with speakers. You can run into problems like phase difference, loss of signal strength.
(That is why amplifiers are normally placed by speakers in longer
FOH distances, instead of by the sound board)
Connections are always a big problem, more so than distances. I always say the less connectors and cable transfers you have to make, the better.