Absolutely, given the right projector(s) with the right output. (You’re gonna want a lot of lumens- unless the place is gonna be pitch black) It’s great at stuff like this- it’s pretty much what it was designed for. You can also control it with DMX through Artnet.I’ve used it off and on for...
You could also use a digital projector or two, with a program like MadMapper which you can load video clips into so in this case some animated lightning- then use the software to mask out places you don’t want the lightning projected. You can even use the software to warp the image (think...