Not necessarily. Two things come into play with regard to impedance in your coax/antenna/receiver circuit. First, neither the antenna or the receiver is really 50Ω, and in fact they might deviate quite a bit from this ideal rating. Second, the impedance mismatch causes 0.18 dB of loss total, independent of cable length. See Jim Brown's article here for the gory details.
So I say it's just fine to use 75Ω coax cable for your mics, if you use good connectors and good cable with it. 75Ω splitters...yes, if they're high quality (probably not the rat shack variety).