For any fixture that is hung where non-technician traffic is around (backstage, etc) I always fully tighten the pan screw and yoke bolt, as those fixtures and the trees they are clamped onto tend to get bumped into. However, there is rarely anybody but technicians, and non-technicians are informed beforehand not to touch any fixtures unless explicitly instructed to.
Whenever I hang yoke down or with the yoke positioned parallel to the stage (the latter being rather common,) I always fully tighten both bolts.